Abstract
We appreciate Dr Layland et al for their interest, and fully agree with the concern that fractional flow reserve (FFR) may underestimate the functional significance of stenotic lesions in patients with ST-segment elevation myocardial infarction (STEMI).1,2 Increased microvascular resistance may have an influence on FFR by altering distal pressure, which is especially remarkable in the culprit lesions with slow flow. Mostly, previous observations were based on “culprits” in the setting of early after STEMI. To the contrary, our inclusion was totally different from the previous studies. Although our data included a small number of patients with …
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