Abstract
We appreciate this opportunity to respond to the comments provided by Drs Gregg Stone and Gary Mintz. They question the conclusion of our study, in which no correlation was found between the size of the necrotic core determined by virtual histology intravascular ultrasound (VH IVUS) and real histology in a porcine model of coronary artery disease.1 First, Drs Stone and Mintz stress the importance of reliable alignment and matching of corresponding images and state that “ … it is inappropriate to align a given histological section to an IVUS frame and expect high correlation in quantification of individual tissue components.” We acknowledge the potential limitations of such alignment, but we do not agree that the method is inappropriate, because this approach forms the general base for validation of VH IVUS for quantitative tissue mapping.2,3 Second, Drs Stone and Mintz argue that our …
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