Abstract
We appreciate the letter by Drs Egido and Garcia commenting on our recent report in Stroke ,1 which identified increasing levels of psychosocial distress as a significant predictor of incident stroke, particularly hemorrhagic stroke and stroke mortality in a US population–based cohort of black and white community residents aged ≥65 years. Egido et al2 recently reported similar results in a case-control study of 150 younger patients with stroke (mean age, 53.8; range, 18–65 years) from a hospital-based stroke unit in Madrid, Spain, and 300 age-matched neighborhood controls. In their study, patients with stroke were significantly more likely than controls to report moderate and high scores on the Holmes and Rahe Social Readjustment Rating Scale,3 a measure of perceived stressfulness of recently experienced life events. This association was maintained after adjusting for demographics, health behaviors, medical history …
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