Abstract
We thank Sikkel et al for their appreciative letter, particularly focusing on the statistical approach used in our recent work.1 Indeed, physiological parameters of cells from human subjects exhibit considerable and intrinsic interindividual variability, at variance with inbred rodents. Thus, when working on human data, the use of hierarchical statistical analysis is not only the most valid option, but one could say it is mandatory to perform reliable comparisons between normal and diseased states. Hierarchical statistical analysis has been used previously in biomedical research involving human subjects,2 including a recent study comparing mechanical data from single myofibrils isolated from cardiac samples of patients with hypertrophic cardiomyopathy with donor hearts and secondary hypertrophy.3 …
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