Abstract
We are grateful to Csont and Ferdinandy for their letter in response to our recent article.1 We are encouraged by their work, which demonstrated the cardioprotective effect of postconditioning 10 weeks after a subtotal nephrectomy. The 4-week subtotal nephrectomy model is the most widely used model of chronic uremia and displays many of the common characteristics that define the uremic phenotype. The 4-week subtotal nephrectomy model leads to animals that are growth restricted, hypertensive, anemic, dyslipidemic, …
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