Response to Letter Regarding Article, “Effects of Endothelial Dysfunction on Residual Platelet Aggregability After Dual Antiplatelet Therapy With Aspirin and Clopidogrel in Patients With Stable Coronary Artery Disease”

Abstract

We thank Drs Emanuele Barbato and Fabio Mangiacapra for their careful and insightful comments on our article1 demonstrating the correlation between peripheral endothelial function assessed by reactive hyperemia index (RHI) and residual platelet reactivity (RPR). As they pointed out, in our population, there was a higher rate of patients with multivessel disease (MVD) in the high RPR group. This might be because it was a selected population without CYP2C19*2 or *3 loss-of-function alleles. We could not demonstrate the correlation between RPR and the severity and extent of coronary artery disease (CAD) because the sample size was limited. However, we …