Abstract
We thank Dr Patel and colleagues for the very positive letter regarding our article on chromosome 9p21 and prognosis in patients with coronary artery disease.1 They observed findings similar to our data that the 9p21 locus (rs10757278) was not associated with risk of major adverse events in >2400 white patients, with a trend toward a protective effect. Patel et al suggested several potential explanations for why we did not observe an increased risk for the cardiovascular outcome with the widely reported risk allele for heart disease in 2 cohorts of patients with existing coronary artery disease. We agree that our cohort (mean age, 68.5 years) and theirs (mean age, 65 years) are older than most of the association studies of 9p21 and heart disease. According to a recent meta-analysis, 9p21 risk alleles are more strongly associated with incidence of heart disease in …
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