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HomeCirculationVol. 122, No. 6Response to Letter Regarding Article, “Association of Circulating Cholesteryl Ester Transfer Protein Activity With Incidence of Cardiovascular Disease in the Community” Free AccessLetterPDF/EPUBAboutView PDFView EPUBSections ToolsAdd to favoritesDownload citationsTrack citationsPermissions ShareShare onFacebookTwitterLinked InMendeleyReddit Jump toFree AccessLetterPDF/EPUBResponse to Letter Regarding Article, “Association of Circulating Cholesteryl Ester Transfer Protein Activity With Incidence of Cardiovascular Disease in the Community” Ramachandran S. Vasan, MD, Michael J. Pencina, PhD, Sander J. Robins, MD and Ralph B. D'Agostino, PhD Guneet Kaur, PhD Justin P. Zachariah, MD Jose M. Ordovas, PhD Ramachandran S. VasanRamachandran S. Vasan Framingham Heart Study, Framingham, Mass Search for more papers by this author , Michael J. PencinaMichael J. Pencina Framingham Heart Study, Framingham, Mass Search for more papers by this author , Sander J. RobinsSander J. Robins Framingham Heart Study, Framingham, Mass Search for more papers by this author and Ralph B. D'AgostinoRalph B. D'Agostino Framingham Heart Study, Framingham, Mass Search for more papers by this author Guneet KaurGuneet Kaur Department of Mathematics and Statistics, Boston University, Boston, Mass Search for more papers by this author Justin P. ZachariahJustin P. Zachariah Department of Cardiology, Children’s Hospital Boston and Department of Pediatrics, Harvard Medical School, Boston, Mass Search for more papers by this author Jose M. OrdovasJose M. Ordovas Lipid Metabolism Laboratory, Jean Mayer USDA Human Nutrition Research Center on Aging, Tufts University, Boston, Mass Search for more papers by this author Originally published10 Aug 2010https://doi.org/10.1161/CIRCULATIONAHA.110.951822Circulation. 2010;122:e421We thank Dr Quintão for correctly noting that the recent prospective analysis from our group using Framingham Offspring Study data indicated an inverse association of plasma cholesteryl ester transfer protein activity with the incidence of cardiovascular disease events,1 whereas a prior publication noted a direct relation of plasma cholesteryl ester transfer protein activity with the prevalence of coronary heart disease.2 We submit that differences in study design (prospective versus cross-sectional) likely account for these differences. We also submit that the risk of cardiovascular disease associated with any potential biomarker is best evaluated by longitudinal studies. Indeed, a recent study reported a similar inverse relation of plasma cholesteryl ester transfer protein concentration and cardiovascular mortality in a high-risk sample.3DisclosuresNone. References 1 Vasan RS, Pencina MJ, Robins SJ, Zachariah JP, Kaur G, D'Agostino RB, Ordovas JM. Association of circulating cholesteryl ester transfer protein activity with incidence of cardiovascular disease in the community. Circulation. 2009; 120: 2414–2420.LinkGoogle Scholar2 Ordovas JM, Cupples LA, Corella D, Otvos JD, Osgood D, Martinez A, Lahoz C, Coltell O, Wilson PW, Schaefer EJ. Association of cholesteryl ester transfer protein-TaqIB polymorphism with variations in lipoprotein subclasses and coronary heart disease risk: the Framingham study. Arterioscler Thromb Vasc Biol. 2000; 20: 1323–1329.CrossrefMedlineGoogle Scholar3 Ritsch A, Scharnagl H, Eller P, Tancevski I, Duwensee K, Demetz E, Sandhofer A, Boehm BO, Winkelmann BR, Patsch JR, März W. Cholesteryl ester transfer protein and mortality in patients undergoing coronary angiography: the Ludwigshafen Risk and Cardiovascular Health study. Circulation. 2010; 121: 366–374.LinkGoogle Scholar Previous Back to top Next FiguresReferencesRelatedDetails August 10, 2010Vol 122, Issue 6 Advertisement Article InformationMetrics https://doi.org/10.1161/CIRCULATIONAHA.110.951822 Originally publishedAugust 10, 2010 PDF download Advertisement SubjectsEpidemiologyMetabolism
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