Abstract
It is now clear that release of metalloproteinase–9 (MMP-9)2 inhibition by tissue inhibitor of MMP-1 (TIMP-1)1 is beneficial during the acute phase of CVB3 myocarditis, but chronic MMP activation is detrimental3 after infection has been cleared. We investigated the course of coxsackievirus B3 (CVB3)–induced viral myocarditis within a murine MMP-9 knockout model.2 On accumulating initial data, it was clear that a detailed study was required to support our observation that MMP-9 was protective during acute CVB3 infection and myocarditis. We noted that CVB3 infection within the pancreas and liver was also higher in the MMP-9 …
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