Abstract
Response: We appreciate the letter from Pfeilschifter et al1 regarding our article in which we demonstrated that activation of sphingosine 1-phosphate receptor-1 (S1P1) by FTY720 is neuroprotective against cerebral ischemia through the prevention of caspase-dependent apoptosis in neurons. Both lymphocytes and vascular endothelial cells have S1P1,2 through which FTY720 may exert protective effects against ischemic brain. However, neurons also have S1P1, and S1P1 expression on neurons is preserved even after middle cerebral artery occlusion, as we demonstrated in our study.1 Despite efforts to develop novel agents to rescue neurons from neuronal death in penumbra where apoptotic events occur, few currently …
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