Abstract
Response: We appreciate the kind comments from Drs Hadjiev and Mineva in their Letter to the Editor regarding our article on the beneficial effect of normobaric hyperoxia (NBO) in reducing the neurovascular complications associated with delayed tPA treatment.1 Animal and human studies have suggested that MMP-9 induction is closely linked to tPA-induced intracerebral hemorrhage in ischemic stroke, the most feared neurovascular complication in tPA thrombolysis. In our article, …
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