Abstract
In the Research Focus article by Toni Kutchan [1], published in this issue of Trends in Biotechnology, Kutchan concludes that genetic engineering can be used to introduce new natural products in a plant with only marginal inadvertent effects. A prerequisite for a successful approach is thorough biochemical understanding of the metabolic pathway to be altered or introduced. We fully agree. But how do these marginal inadvertent effects in a plant compare with natural variation?
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