Abstract
To the Editor: We sincerely thank Dr Keszthelyi for his letter (1) regarding our recent study using imipramine in treatment of esophageal hypersensitivity and functional heartburn (2). We greatly appreciate his comments with regard to the differences in the enzyme system, CYP2D6 and CYP2C19, responsible for tricyclic antidepressants (TCAs) metabolism among Asians and Caucasians making generalization of our findings difficult among Caucasians.
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