Response to Endothelial Dysfunction, Isoprostanes, and Copper Deficiency

Abstract

HomeHypertensionVol. 52, No. 3Response to Endothelial Dysfunction, Isoprostanes, and Copper Deficiency Free AccessLetterPDF/EPUBAboutView PDFView EPUBSections ToolsAdd to favoritesDownload citationsTrack citationsPermissions ShareShare onFacebookTwitterLinked InMendeleyReddit Jump toFree AccessLetterPDF/EPUBResponse to Endothelial Dysfunction, Isoprostanes, and Copper Deficiency Shahar Lavi and Amir Lerman Shahar LaviShahar Lavi Division of Cardiovascular Diseases, Mayo Clinic, Rochester, Minn Search for more papers by this author and Amir LermanAmir Lerman Division of Cardiovascular Diseases, Mayo Clinic, Rochester, Minn Search for more papers by this author Originally published28 Jul 2008https://doi.org/10.1161/HYPERTENSIONAHA.108.116475Hypertension. 2008;52:e28Other version(s) of this articleYou are viewing the most recent version of this article. Previous versions: July 28, 2008: Previous Version 1 We appreciate Klevay’s comments1 regarding the potential role of copper supplement for the treatment of endothelial dysfunction. Our study focused on the association among coronary endothelial dysfunction, local bioavailability of NO, and local reactive oxygen species generation.2 We demonstrated that, in patients with endothelial dysfunction, there is increased local ROS generation, reduced activity of antioxidants (superoxide dismutase) and preserved production of NO. However, there was no significant difference in the arterial levels of either isoprostanes or superoxide dismutase between patients with coronary endothelial dysfunction and patients with normal response to acetylcholine. The relationship among copper deficiency, isoprostanes, superoxide dismutase, and arterial response to acetylcholine3 is indeed very intriguing. Thus, it may be speculated that the relative deficiency of copper as a central molecule in the antioxidant axis may play a role in the mechanism of endothelial dysfunction.It should be noted that, although copper deficiency may have adverse effects on the cardiovascular system, high copper levels are associated with increased risk of death from cardiovascular disease. In fact, even the second quartile of copper was associated with a trend toward increased risk compared with the lowest quartile (hazard ratio: 1.84).4 Increased copper levels were also an independent predictor for acute myocardial infarction.5The use of copper in medicine dates to Hippocrates, but there are not much data to support its use in cardiovascular disease. The effect of antioxidants on endothelial function should be studied. Copper, an antioxidant nutrient, would be a potential agent.Sources of FundingThis study was supported by NIH grants K24, HL-69840, and R01 HL-63911 and the Mayo Foundation.DisclosuresNone.1 Klevay LM. Endothelial dysfunction, isoprostanes, and copper deficiency. Hypertension. 2008; 52: e27.LinkGoogle Scholar2 Lavi S, Yang EH, Prasad A, Mathew V, Barsness GW, Rihal CS, Lerman LO, Lerman A. The interaction between coronary endothelial dysfunction, local oxidative stress, and endogenous nitric oxide in humans. Hypertension. 2008; 51: 127–133.LinkGoogle Scholar3 Lynch SM, Frei B, Morrow JD, Roberts LJ II, Xu A, Jackson T, Reyna R, Klevay LM, Vita JA, Keaney JF Jr. Vascular superoxide dismutase deficiency impairs endothelial vasodilator function through direct inactivation of nitric oxide and increased lipid peroxidation. Arterioscler Thromb Vasc Biol. 1997; 17: 2975–2981.CrossrefMedlineGoogle Scholar4 Ford ES. Serum copper concentration and coronary heart disease among US adults. Am J Epidemiol. 2000; 151: 1182–1188.CrossrefMedlineGoogle Scholar5 Salonen JT, Salonen R, Korpela H, Suntioinen S, Tuomilehto J. Serum copper and the risk of acute myocardial infarction: a prospective population study in men in eastern Finland. Am J Epidemiol. 1991; 134: 268–276.CrossrefMedlineGoogle Scholar Previous Back to top Next FiguresReferencesRelatedDetailsCited By Suliburska J, Bogdański P, Pupek-Musialik D and Krejpcio Z (2010) Dietary Intake and Serum and Hair Concentrations of Minerals and their Relationship with Serum Lipids and Glucose Levels in Hypertensive and Obese Patients with Insulin Resistance, Biological Trace Element Research, 10.1007/s12011-010-8650-0, 139:2, (137-150), Online publication date: 1-Feb-2011. September 2008Vol 52, Issue 3 Advertisement Article InformationMetrics https://doi.org/10.1161/HYPERTENSIONAHA.108.116475 Originally publishedJuly 28, 2008 PDF download Advertisement SubjectsHypertension