Abstract
From 1987 to the present our Cuban Centre has performed more than 30 foetal nigral transplants to the striatum in patients with Parkinson’s disease. To study the improvement reported in dopaminergic drug response and the decrease L-Dopa daily dose together with better motor performance /1/, the present pharmacological trial was applied to four Parkinsonian patients, who underwent stereotactic implantations of foetal ventral mesencephalon dissociated cells. Four male patients with idiopathic Parkinson’s disease were studied during their hospitalization (approximately one year). They were diagnosed and followed clinically according to the CAPIT recommendations. Using stereotactic technique we performed computer-assisted CT-guided transplantation of foetal mesencephalic cell suspensions to the right striatum of the four patients. The clinical evolution was evaluated by a single L-Dopa response test and the apomorphine dose-response curve (using 1 mg to 4 mg) before, and 30, 60 and 90 days after surgery. Biochemical studies included the measurement of L-Dopa, 3-O-methyl-dopa and catecholamine catabolites in CSF by HPLC pre-operatively and 60 days after the implant. Statistical analyses were performed by Wilcoxon paired rank test and lineal correlation methods. Changes in the rates of the response (increase of on phase duration and decrease in on
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