Abstract
To the Editor: We thank Doherty et al. (1) for their interest in our article as well as for their valuable comments. The data in our meta-analysis (2) and our conclusions were based on prior studies included in the analysis. We realize that many of the studies had limitations that would influence the interpretation of our data. For example, it is clear that false-positive capsule endoscopy (CE) findings as well as selection bias in the published studies we analyzed are among the limitations. In the only prospective, blinded study comparing CE, computed tomography (CT) enterography, small bowel radiography and colonoscopy, the sensitivity of CE and CT enterography was identical. However, the specificity of CE was significantly lower than other tests (3) possibly indicating higher false-positive rate. We thoroughly agree with Dougherty et al. (1) that a standardized grading scale for CE findings is indeed important and should be applied to future studies to improve specificity and overall diagnostic accuracy of CE in the diagnosis of small bowel inflammation and suspected Crohn's disease.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
