Response to comments on: Choroidal and retinal thickness variations in ocular albinism.

Abstract

Dear Editor, We read with great interest the authors’ reply to our research paper on retinal and choroidal thickness variations in eyes with ocular albinism.[1,2] Albinism is a genetic disease characterized by hair, skin, and eye hypopigmentation.[3] In addition to high refractive errors, iris and fundus hypopigmentation, and optic nerve misdirection, eyes with ocular albinism have foveal hypoplasia, nystagmus, and poor vision.[4,5] Image acquisition for optical coherence tomography (OCT) and OCT angiography in albinotic eyes is extremely difficult due to nystagmus, poor vision, and a lack of foveal contour. As a result, we believe that examining the adjacent infrared fundus image of multiple single-line OCT scans and selecting the scan most likely to pass through the anatomic fovea is the best technique for foveal identification. Various publications use different definitions and techniques to measure choroidal thickness in various clinical situations and on various OCT devices.[6,7] Using the 1:1 pixel protocol, we manually measured the choroidal thickness from the outer border of the retinal pigment epithelium to the inner boundary of the sclera in our study. We believe that the results will be extremely reliable and comparable until the protocol for measuring retinal and choroidal thicknesses is uniformly applied across all of the study OCT scans, including both the cases and the control group. Finally, we must admit that obtaining high-quality OCT scans that pass through the fovea and accurately measuring retinal and choroidal thicknesses in albinotic eyes is a serious challenge.