Response to Comment on “The Arabidopsis Circadian Clock Incorporates a cADPR-Based Feedback Loop”

Abstract

Xu et al . were unable to measure circadian oscillations of cyclic adenosine diphosphate ribose (cADPR). Their experiments showing very low concentrations of cADPR lack appropriate controls, which suggests that technical limitations might explain their negative result. Xu et al . also report that chemically induced ADP ribosyl cyclase did not alter clock function, which exactly replicates our findings.