Response to comment on: Goldberg et al. Circadian variation in the response to the glucose challenge test in pregnancy: implications for screening for gestational diabetes mellitus. Diabetes Care 2012;35:1578-1584.

Abstract

We thank Dokus and Dokusova (1) for their interest in our recent article on circadian variation in the response to the glucose challenge test (GCT) in pregnancy and its implications for screening for gestational diabetes mellitus (GDM) (2). In this study, 927 pregnant women with a positive GCT underwent metabolic characterization with a 3 h 100-g oral glucose tolerance test (OGTT). Metabolic characteristics were compared across the following four groups that were defined based on time of day of the GCT: before 9:00 ( n = 171); 9:00–10:59 ( n = 288); 11:00–12:59 ( n = 189); and after 13:00 ( n = 279). This analysis revealed that, when compared on subsequent OGTT, women with a positive GCT in the …