Response to Comment on Braffett et al. Association of Insulin Dose, Cardiometabolic Risk Factors, and Cardiovascular Disease in Type 1 Diabetes During 30 Years of Follow-up in the DCCT/EDIC Study. Diabetes Care 2019;42:657-664.

Barbara H Braffett,Ionut Bebu,William I Sivitz,Orville Kolterman,Samuel Dagogo-Jack,John M Lachin,Mary Larkin

doi:10.2337/dci19-0026

Response to Comment on Braffett et al. Association of Insulin Dose, Cardiometabolic Risk Factors, and Cardiovascular Disease in Type 1 Diabetes During 30 Years of Follow-up in the DCCT/EDIC Study. Diabetes Care 2019;42:657-664.

Barbara H Braffett, Ionut Bebu + Show 5 more

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https://doi.org/10.2337/dci19-0026

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Journal: Diabetes care	Publication Date: Jul 12, 2019
Citations: 4	License type: NO-CC CODE

Affiliation: George Washington University, University of Iowa, University of California, San Diego, University of Tennessee Health Science Center, Massachusetts General Hospital

#Diabetes Control And Complications Trial/Epidemiology Of Diabetes Interventions And Complications #Adverse Cardiometabolic Profile + Show 8 more

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Abstract

Snaith et al. (1) suggest that the relationship between insulin dose and adverse cardiometabolic profile might be mediated by insulin resistance and cite data linking clamp-derived measurement of insulin resistance and coronary artery calcification (2). We do not have any direct assessment of insulin resistance in the Diabetes Control and Complications Trial/Epidemiology of Diabetes Interventions and Complications (DCCT/EDIC) study; however, the association among weight gain, insulin resistance, and adverse …

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