Abstract
Causes for perioperative respiratory complications include anesthetic-and opioid-in-duced reduced ventilatory drive.1 Previous studies predominantly described the influence of single agents on the performance of the controller. Since in clinical practice an anesthetic is combined with an opioid, we designed a study on the interaction of an inhalational anes-thetic, sevoflurane, and an opioid, alfentanil, on ventilation and heart rate during normoxia and acute isocapnic hypoxia. In the next section, we first review possible methodologies to quantify pharmacodynamic interactions. Subsequently we describe the analysis of the experimental data.KeywordsResponse Surface ModelingSevoflurane ConcentrationVentilatory DriveRichards ModelHypoxic SensitivityThese keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
Sign-in/Register to access full text options 
Free) 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
