Abstract
The combined effects of perfluorocarbon and glucose concentrations on actinorhodin production by Streptomyces coelicolor A3(2) were studied in a 2-l bioreactor using response surface methodology. A 2 2 full-factorial central composite design was employed for experimental design and analysis of the results. The optimum PFC and glucose concentrations were found to be 42.7% and 12.25 g/l, respectively. In these conditions, actinorhodin concentration of 60 mg/l with a biomass concentration of 1.9 g/l, a maximum volumetric oxygen uptake rate of 180 mgO 2/l h and a glucose consumption rate of 0.110 g glucose/l h was attained. These results are in close agreement with the model predictions.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Disclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.