Abstract
BackgroundThe purpose of the present study was to evaluate layered of satranidazole powder using natural polysaccharides as coating materials for colon targeting that were inexpensive and natural with a non-toxic nature using a composite response design of 3 levels and 2 factors for each of the four responses in the quadratic model. The independent variables were the ratio of coating consistency % (X1) and coating level % (X2) in the pellet. The dependent factors were % release of drug at 2 h. (Y1), % release of drug at 6 h. (Y2), % release of drug difference in presence & absence of colonic enzyme (Y3) and mean dissolution time (Y4). The various models were fitted for the responses with an explanation of suitable statistical methods. Variance analysis and different factor levels of responses were constructed by response surface plots.ResultsSatranidazole pellets were efficiently prepared by the variable amount of ingredients that showed compatibility with possible pellet characterization and drug dissolution profiles to optimize the formulation.ConclusionsThe strategy of response surface can be a successful tool for improving the prepared satranidazole pellets which can be an appropriate replacement of regular one.
Highlights
The purpose of the present study was to evaluate layered of satranidazole powder using natural polysaccharides as coating materials for colon targeting that were inexpensive and natural with a non-toxic nature using a composite response design of 3 levels and 2 factors for each of the four responses in the quadratic model
It was revealed that the proper response surface design can be used effectively in enhancing satranidazole pellets to meet colonic release
The surface response graphs and optimization allowed the satranidazole pellets to be layered by a combination of natural polysaccharides with the required release profile
Summary
The purpose of the present study was to evaluate layered of satranidazole powder using natural polysaccharides as coating materials for colon targeting that were inexpensive and natural with a non-toxic nature using a composite response design of 3 levels and 2 factors for each of the four responses in the quadratic model. (Y2), % release of drug difference in presence & absence of colonic enzyme (Y3) and mean dissolution time (Y4). Satranidazole has better patient compliance and Statistical experimental design technique is a classical tool useful for the optimization and characterization of pharmaceutical processes by studying the effects of variables with their interaction [6]. The experimental models can be optimized by considering independent and dependent variables to keep the process in a systemic and rapid mode [8]. A suitable method design can be useful for the optimization of pellets instead of the conventional optimization
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