Abstract
Of all cells in the human body, erythrocytes express the highest level of the GLUT1 glucose transporter, with more than 200,000 molecules per cell (Mueckler et al., 1985). We found that GLUT1 expression is significantly upregulated in late-stage erythroblasts, whereas glucose transport is decreased (Montel-Hagen et al., 2008a). This increase in GLUT1 expression was associated with enhanced transport of L-dehydroascorbic acid (DHA), an oxidized intermediate of ascorbic acid (AA). Moreover, the efficient capture of DHA by erythrocyte GLUT1 and its immediate reduction to AA constitutes a recycling system that has evolved in those mammals incapable of synthesizing vitamin C.
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