Abstract
The transplantable Guerin epithelioma in Wistar rats was used to test the in vivo effectiveness of 1-(2-hydroxy-3-methoxypropyl)-2-methyl-4-nitroimidazole (P1) as a tumour-cell radiosensitizer after its oral administration at relatively low doses. The radiosensitizing ability of P1 was compared with that of metronidazole. The results indicate that P1 is less toxic than metronidazole, and greater concentrations of P1 in blood and tumour tissues are obtained for the same administered dose of the compounds. The radiosensitizing ability of P1, determined from tumour-regression rates and local-control percentage at 130 days, was higher than that of metronidazole.
Highlights
Summary.-The transplantable Guerin epithelioma in Wistar rats was used to test the in vivo effectiveness of 1-(2-hydroxy-3-methoxypropyl)-2-methyl-4-nitroimidazole (P1) as a tumour-cell radiosensitizer after its oral administration at relatively low doses
Wistar rats were used at an age of about 3 months
The concentration of compounds in blood and tumour tissue wvas estimated in the ethanol supernatants by spectrophotometry at 314 nm and 302 nm (P1), according to the method described by Urtasun et al (1975)
Summary
The solid Guerin epithelioma (Guerin & Guerin, 1934) has been passaged for many generations in this laboratory This tumour has a volume-doubling time during the exponential period of growAth in the range of 3-14-3 days, with a mean of 3-7 + 0-6 days. Both nitroimidazoles wvere given orally dissolved in water (P1) or in suspension (mnetronidazole) at doses of 0 15-0 6 g/kg body wt. Pi acute toxicity test.-The LD50 was determined by giving animals (C3H mice and Wistar rats) graded doses of compound P1 orally and observing deaths among the animals at 2 and 30 days. The aniinals received 10 doses 3 times weekly and the volume changes of tumours were measured.
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