Response of the coyote to endotoxin.

Abstract

SummaryResponses of the coyote to E. coli endotoxin have been studied in animals intravenously anesthetized with sodium pentobarbital. Major results reveal portal hypertension concomitant with systemic hypotension; hemoconcentration; depressed liver function; hepatic, renal and adrenal congestion; intestinal necrosis and gall bladder edema. The liver appears to be the primary “target organ” of endotoxin in regard to hemodynamic, histological, and functional abnormalities. The coyote is more resistant to endotoxin than its domestic counterpart in terms of changes in hemodynamics and survival ability.