Response of the adult prostate to prepubertal and postpubertal obstruction of the vas deferens in the rat

Abstract

Objectives. To determine whether obstruction of the vas deferens alters several general measures of prostate development during puberty and during prostate maintenance in the adult rat. Previous reports have suggested the possibility that vasectomy results in alterations of prostate function in experimental animals and humans. Methods. Adult rats and 10-day-old rats were subjected to bilateral sham operations or bilateral vasectomy, and the prostates were extirpated either 14 or 60 days later. The total prostate weight and dorsolateral and ventral lobe total protein per milligram tissue, DNA per milligram tissue, and DNA per milligram protein were determined. Dorsolateral and ventral prostate lobe sections from each group were also stained with hematoxylin-eosin and subjected to histologic examination. Results. The histologic features of the adult rat prostate were not qualitatively altered by vasectomy whether it occurred before puberty or in adult animals with mature prostates. Furthermore, vasectomy did not significantly alter the prostate weight or the protein or DNA content of either the dorsolateral or ventral lobes of the prostate compared with the sham-operated animals of either age. Conclusions. Vas deferens obstruction does not significantly alter the parameters associated with the development or maintenance of the adult rat prostate measured in this study.