Abstract
Previous studies have shown that administration of dehydroepiandrosterone (DHEA) results in decreased weight gain in several strains of rat. In the present study, sucrose-fed female BHE rats treated with DHEA also had a decrease in weight and food efficiency ratio. In addition, a decrease in glucose-6-phosphate dehydrogenase activity was found in liver. Adipose tissue cellularity was also decreased in DHEA treated rats. DHea treatment did not alter serum cholesterol, liver cholesterol levels or ACAT activity but did decrease total body cholesterol. An increase in long-chain fatty acyl-CoA hydrolase activity further supported the hypothesis that a futile or substrate cycle may be induced by DHEA. Results of this study suggest that DHEA's ability to inhibit glucose-6-phosphate dehydrogenase may only be of biological significance in vivo when the activity of the enzyme is elevated.
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