Response of some indicators of the respiratory system to dosed hypoxia in elderly people with impaired glucose tolerance

Abstract

Abstract. The response of the respiratory system to dosed hypoxia (breathing with a gas mixture of 12% oxygen for 20 min) in the elderly with impaired (n = 35) and preserved glucose tolerance (n = 33) was studied. It is shown that the increase in lung ventilation occurs regardless of the state of carbohydrate metabolism in hypoxia. In people with impaired glucose tolerance, changes in lung ventilation in hypoxia are less significant than in people with persistent glucose tolerance. In persons with impaired glucose tolerance, an inverse relationship was found between the increase in pulmonary ventilation during hypoxia and insulin resistance (r = -0.26, p = 0.035), as well as between the increase in pulmonary ventilation during hypoxia and plasma glucose concentration due to 2 hours of standard glucose tolerance test (r = -0.31, p = 0.012). It is concluded that there is a causal relationship between impaired glucose tolerance and insufficient response of pulmonary ventilation to hypoxia in the elderly. Keywords: elderly; impaired glucose tolerance; hypoxia; ventilation.