Response of red cell phosphate to acute and chronic changes in plasma phosphate in man.

Abstract

Inorganic phosphate (Pi) is known to participate in many biochemical reactions and is a regulator in several metabolic pathways (1). In the red blood cell the structural integrity of the membrane is dependent on metabolic energy derived from glycolysis to produce ATP (2). Pi plays a major role in the red blood cell in regulating the concentrations of ATP and 2,3-diphosphoglycerate (3). In spite of the increasing knowledge about phosphate depletion syndromes, there is still a debate about the mechanisms of phosphate transport across cell membranes and about factors which control its extracellular and intracellular concentrations.KeywordsWhole BloodDichloro MethylenePlasma PhosphateHexose PhosphateMethylene DiphosphonateThese keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.