Abstract
Meeting Abstracts1 May 1970Response of Polycythemia to Treatment with a New Agent: Hydroxyurea.W. O. West, M.D., (Associate), J. D. Ruff, M.D., (Associate), J. W. Yarbro, M.D., F.A.C.P.W. O. West, M.D., (Associate)Search for more papers by this author, J. D. Ruff, M.D., (Associate)Search for more papers by this author, J. W. Yarbro, M.D., F.A.C.P.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-72-5-795_3 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptThe purpose of this study was to determine the efficacy and safety of hydroxyurea in the management of polycythemia vera. Hydroxyurea is effective in the control of chronic myelogenous leukemia. It has recently been reported to produce marked improvement in patients with refractory psoriasis. It is a specific inhibitor of deoxyribonucleic acid synthesis, acting at the level of conversion of ribonucleotides to deoxyribonucleotides, and its effectiveness as a inhibitor of erythropoiesis is demonstrated by the regular production of megaloblasts in the bone marrow. The earliest sign of therapy with hydroxyurea is a fall in the reticulocyte count which may be... This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Lexington, Ky. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byPolycythemia vera: historical oversights, diagnostic details, and therapeutic viewsMyeloproliferative neoplasms: A decade of discoveries and treatment advancesThe history of myeloproliferative disorders: before and after Dameshek 1 May 1970Volume 72, Issue 5Page: 795-795KeywordsBone marrowChronic myelogenous leukemiaErythropoiesisFallsPolycythemiaPolycythemia veraPsoriasisReticulocytesSafetySafety studies Issue Published: 1 May 1970 PDF downloadLoading ...
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