Abstract
Gregory and Tracy1 have isolated and with their colleagues2,3 have synthesized the antral hormone, gastrin, which has proved to be the most potent stimulant of gastric acid secretion. Tracy and Gregory4 showed in the dog that all the physiological actions of the heptadecapeptide gastrin molecule could be produced by the carboxy-terminal tetrapeptide amide try.met.asp.phe-NH2. Morley, Tracy and Gregory5 showed that several derivatives of this tetrapeptide also exhibited the full range of physiological activities of natural gastrin.
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