Response of Hepatic Enzyme Activities to Castration and Sarcoma 37 Growth in Different Mouse Genotypes<xref ref-type="fn" rid="FN1">2</xref>

Abstract

The influences of strain genome, agouti locus genotype, castration, and subcutaneous growth of Sarcoma 37 cells on catalytic capacities of the liver with respect to several enzymes were investigated in strains YS and VY male mice at 14 weeks of age. In the VY strain, citrate cleavage enzyme, malic enzyme, serine dehydratase, and tyrosine α-ketoglutarate transaminase capacities were higher than in the YS strain. Among VY animals, yellow mice had greater glucokinase, malic enzyme, and citrate cleavage enzyme capacities than their black sibs. In the YS strain, however, only the catalytic capacity of malic enzyme was greater in yellow mice than in their black sibs. Castration altered the hormonal balance on a long-term basis; tumor cell growth changed it on a short-term basis. No uniform associations of changes in plasma corticosterone or serum insulin levels with changes in catalytic capacity of hexokinase, glucokinase, citrate cleavage enzyme, malic enzyme, serine dehydratase, tyrosine a-ketoglutarate transaminase, or ornithine transaminase were observed.