Abstract
The odontogenic epithelium of the Swiss-strain mice has been shown to be extremely susceptible to 3-methylcholanthrene. In our second group of animals, malignant tumours of the odontogenic epithelium were produced in over 80 per cent of the animals in approximately 2–2 1 2 months. The tumours were epithelial, usually squamous in character; however, several showed a variation to a spindle cell or papillary configuration. The tumours destroyed the normal architecture of the mandible and invaded contiguous tissues and in several instances caused death of the animal. The establishment of the odontogenic epithelium as an easily accessible and highly susceptible tissue to 3-methylcholanthrene allows for further investigation into the physical and chemical nature of the neoplastic cell.
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