Response of creatine kinase and lactate dehydrogenase enzymes to rest interval between sets and set-repetition configuration during bouts of eccentric exercise.

Abstract

Background and aimsVarious studies have demonstrated that different rest intervals and set-repetition have a significant effect on hormonal and metabolic responses. These factors can lead to different muscle damage responses.MethodsForty untrained subjects (25.4 ± 0.068 years, height: 1.74 ± 0.97 cm, and weight: 30.8 ± 8.48 kg) in three sessions of eccentric resistance exercise with 24-h rest between each session participated in this study. Subjects were divided into four groups of 10 subjects who performed 50 eccentric contractions with different number of 5 and 10 sets, 5 and 10 repetitions, and the interset rest interval 1 and 3 min with 85% of one repetition maximum (1RM). Creatine kinase and lactate dehydrogenase were measured immediately before each session, immediately after each session, and 24 h after the last training session. Variance analysis with repeated measurement and Bonferroni post hoc test were used for statistical analysis of data.ResultsThere is no significant difference in creatine kinase and lactate dehydrogenase between four groups at different time points (p < 0.05).ConclusionThe repetition of eccentric exercise for three consecutive days causes muscle damage that is independent of manipulating the interset rest intervals and the number of set-repetition.