Abstract
Background: Systemic inflammation due to radiation exposure has been identified in a biological system by certain metabolic and behavioral disorders. These anarchies mostly mediated under a regulation of cyclooxygenase 2 (COX2) induced production of an inflammatory mediator prostaglandin E2 (PGE2). Aim: This study was undertaken to investigate the anti-inflammatory impact of brown sea weed extract (BSWE) against induction of COX2/PGE2 inflammatory pathway in gamma-irradiated rats. Rats were orally administrated with BSWE (27 mg/kg body weight/day) for 7 consecutive days before exposure to 8 Gy fractionated gamma radiation (2 Gy × 4; every 3 days). Treatment with BSWE was extended along with and in-between irradiation doses for another 14 successive days. Our data demonstrated that the administration of BSWE to rats exposed to gamma radiation, following the regimen suggested, significantly neutralize the changes induced in the inflammatory molecules COX2, PGE2, tumor necrosis alpha (TNF-α), and nitric oxide (NO). In addition, it adjusted significantly the cellular redox tone via regulation of changes induced in malondialdehyde (MDA) reduced glutathione (GSH), superoxide dismutase (SOD) catalase (CAT) and xanthine oxidoreductase system (XOR). Credibly, from the results emerged in this study, it could be suggested that BSWE has substantial anti-inflammatory activities and gamma radiation protection capabilities. It is recommended to include BSWE in the treatment strategy of various inflammatory diseases especially cancer as a safe natural anti-inflammatory agent.
Highlights
Inflammation is part of the body’s immune response
Our data demonstrated that the administration of brown sea weed extract (BSWE) to rats exposed to gamma radiation, following the regimen suggested, significantly neutralize the changes induced in the inflammatory molecules cyclooxygenase 2 (COX2), prostaglandin E2 (PGE2), tumor necrosis alpha (TNF-α), and nitric oxide (NO)
The administration of SW to normal rats does not induce any significant changes in COX2, and PGE2, TNF-α, and NO concentration comparing with control rats
Summary
Inflammation is part of the body’s immune response. It happened when something harmful or irritating affects a part of the body and there is a biological response to try to remove it. Infection is caused by a bacterium, virus or fungus, while inflammation is the body’s response to it including the local reactions and the destruction changes; the destruction was affected by brown seaweed extract and the responses that lead to repair and healing [1]. Systemic inflammation due to radiation exposure has been identified in a biological system by certain metabolic and behavioral disorders These anarchies mostly mediated under a regulation of cyclooxygenase 2 (COX2) induced production of an inflammatory mediator prostaglandin E2 (PGE2). Our data demonstrated that the administration of BSWE to rats exposed to gamma radiation, following the regimen suggested, significantly neutralize the changes induced in the inflammatory molecules COX2, PGE2, tumor necrosis alpha (TNF-α), and nitric oxide (NO). It is recommended to include BSWE in the treatment strategy of various inflammatory diseases especially cancer as a safe natural anti-inflammatory agent
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