Abstract
5 min foot-shock resulted in an elevation in levels of immunoreactive (ir)-dynorphin (DYN) and ir-vasopressin (VP) in the hypoathalamus whereas their levels were not significantly modified in the neurointermediate pituitary. In the anterior pituitary, however, a fall in ir-DYN in the absence of any change in ir-VP was detected. Further, in the thalamus and medulla/pons, respectively, a decrease and increase in levels of ir-VP was observed whilst the content of ir-DYN therein was not significantly affected. These findings support the concept of a common origin and co-modulation of DYN and VP in the hypothalamic- neural lobe axis and that, extrinsic to this, DYN and VP are localized and modulated independently of each other.
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