Abstract
Aristolochia longa is widely used in traditional medicine in Algeria to treat breast cancer. The aim of the present study was to investigate the response of bone resorption markers to A. longa intake by Algerian breast cancer postmenopausal women. According to the A. longa intake, breast cancer patients were grouped into A. longa group (Al) (n = 54) and non-A. longa group (non-Al) (n = 24). 32 women constituted the control group. Bone resorption markers (from urine) pyridinoline (PYD) and deoxypyridinoline (DPD) were determined by HPLC. Serum and urinary creatinine, uric acid, and urea were measured. 1 g of A. longa intake resulted in significant rise of renal serum markers and a pronounced increase of bone resorption markers. The intake of A. longa roots is detrimental for kidney function and resulted in high bone resorption, maybe due to the reduction in renal function caused by the aristolochic acids contained in the roots.
Highlights
The pyridinium cross-links pyridinoline (PYD) and deoxypyridinoline (DPD) are established markers of bone resorption measured in blood and urine and are used to investigate bone metabolism and manage bone diseases [1]
Deoxypyridinoline (Dpd) distributed mostly in bone collagen has a higher specificity for bone than pyridinoline, which is excreted in urine, and it is not affected by diet, whereas pyridinoline (Pyd) is abundant in bone and cartilage (Figure 1) [2]
According to our results (Table 2), 1 g of A. longa intake resulted in significant rise of renal serum markers
Summary
The pyridinium cross-links pyridinoline (PYD) and deoxypyridinoline (DPD) are established markers of bone resorption measured in blood and urine and are used to investigate bone metabolism and manage bone diseases [1]. Deoxypyridinoline (Dpd) distributed mostly in bone collagen has a higher specificity for bone than pyridinoline (pyd), which is excreted in urine, and it is not affected by diet, whereas pyridinoline (Pyd) is abundant in bone and cartilage (Figure 1) [2]. They are inexpensive, sensitive, and useful for the diagnosis of bone metastasis [3]. Aristolochia longa belongs to the genus Aristolochia (Aristolochiaceae) consisting of about 500 species mostly distributed along tropical, subtropical, and Mediterranean regions of the world [4]. Plants of the genus Aristolochia have been shown to exhibit interesting anticancer activities including cytotoxic and apoptosis-induced, herbal remedies containing plants of Aristolochia genus are banned in many countries because of the nephrotoxicity of their aristolochic acid [6, 7]
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