Abstract
When intracerebral 9L tumors in male Fisher 344 rats were treated with daily fractions of BCNU and X-rays, 5 days per week for 2 weeks, the following were found: (1) there was a significant increase in the life-span of rats treated with the combination treatment schemes over that observed for rats treated with the single agent schemes, (2) the increase in Iife-span in the combination treatments was critically dependent on the time interval between the BCNU and X-ray treatments, (3) increasing the daily dose of BCNU increased the effectiveness of the combination treatments, and (4) the results of the optimum combination treatment were not critically dependent on the tumor size or growth state.
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