Abstract
Administration of propylthiouracil to rats bearing pituitary tumor MtTW5 decreased the rate of tumor growth. When thyroidectomized rats were inoculated with pituitary tumor, no growth of the tumor was observed, nor were any of the hormonally produced effects found. Implantation of thyroid glands or administration of thyroxine caused a prompt restoration of pituitary tumor growth, mammary tumor growth, and a generalized increase in body weight. Thyroidectomy of rats bearing large pituitary tumor caused an immediate cessation of further tumor growth. Slices of liver from tumorbearing rats were incubated in vitro with acetate- l-14C and were found to produce radioactive carbon dioxide and fatty acids at a faster rate than liver slices from normal rats. Whereas liver slices from thyroidectomized rats bearing MtTW5 inoculum metabolized acetate-1-14C at control rates, administration of thyroxine caused the stimulation of pituitary tumor growth, which caused an increase in acetate metabolism by the liver. Retrop...
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
