Abstract
We appreciate Knop's (1) interest in our recent article (2). Although his suggestion that the impaired incretin response observed in subjects with the TCF7L2 variant rs7903146 may be due to insulin resistance and impaired glucose tolerance (IGT) is interesting, this hypothesis is not supported by our data. Insulin sensitivity was measured in both groups using the oral glucose minimal model, which has been validated against the clamp technique (3), and no differences were found (14.2 vs. 15.3 × 103 min−1 per pmol/l; P = 0.42). Although there was a tendency toward a higher BMI in the group with the TCF7L2 variant, the difference did not reach statistical significance. …
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