Abstract
Objective: To explore the effect of comorbid obsessive-compulsive personality disorder (OCPD) on response inhibition functions in patients with obsessive-compulsive disorder (OCD). Methods: Forty-five obsessive-compulsive patients with obsessive-compulsive personality disorder (OCD + OCPD), 42 obsessive-compulsive patients without obsessive-compulsive personality disorder (OCD - OCPD) and 54 healthy volunteers were selected for the stop-signal task. Results: Obsessive-compulsive patients with obsessive-compulsive personality disorder had a higher score of depression and anxiety and more severe obsessive-compulsive symptoms than that of obsessive-compulsive patients without obsessive-compulsive personality disorder. The two groups of obsessive-compulsive patients of had a greater stop-signal reaction time (SSRT) during the inhibition process than the healthy volunteers of the control group (OCD + OCPD: 221.45 ± 31.78; OCD - OCPD: 218.36 ± 31.78; Controls: 199.29 ± 22.80; p < 0.05). However, no significant difference was found between the two groups of obsessive-compulsive patients. Conclusion: The findings show that the comorbid obsessive-compulsive personality disorder has no effect on response inhibition function of obsessive-compulsive patients.
Highlights
obsessive-compulsive disorder (OCD) is often comorbid with a personality disorder (PD), most commonly obsessive-compulsive personality disorder (OCPD), of which the comorbidity rate is 23 % - 32 % [1]
Some studies have shown that OCD patients with OCPD were characterized by a severer compulsive symptom, an earlier age of onset and weaker response to drug treatment . [2,3,4] Based on the difference of clinical manifestations, some researchers believed that OCD comorbid with OCPD might be a sub-type of the OCD [2, 3]
Lochner, et al found that no earlier age of onset was found among the OCD patients with OCPD, and that there was no difference in treatment effect on cognitive behavior [5]
Summary
Forty-five obsessive-compulsive patients with obsessivecompulsive personality disorder (OCD + OCPD), 42 obsessivecompulsive patients without obsessive-compulsive personality disorder (OCD - OCPD) and 54 healthy volunteers were selected for the stopsignal task
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