Abstract
We thank Takov et al for their interest in our study.1 In their letter to the editor, Takov et al raise 3 concerns regarding our study. First, Takov et al pointed out the necessity of including a vehicle control and the importance of administration technique in the in vivo mouse myocardial infarction experiments. Previous study has indicated that vehicle control and sham-operated control show similar effect on post–myocardial infarction healing.2 We completely agree with Takov et al that administration technique is important in cell transplantation. In our study, we intramyocardially inject 1×105 synthetic mesenchymal stem cell (synMSC) particles or mesenchymal stem cells (MSCs) in 50 μL PBS into 4 sites in the border zone …
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