Response by J. Thomas Cribbs & Stefan Strack

Abstract

Correspondence12 October 2007free access Response by J. Thomas Cribbs & Stefan Strack J. Thomas Cribbs J. Thomas Cribbs University of Iowa Carver College of Medicine, Iowa City, Iowa, USA Search for more papers by this author Stefan Strack Corresponding Author Stefan Strack University of Iowa Carver College of Medicine, Iowa City, Iowa, USA Search for more papers by this author J. Thomas Cribbs J. Thomas Cribbs University of Iowa Carver College of Medicine, Iowa City, Iowa, USA Search for more papers by this author Stefan Strack Corresponding Author Stefan Strack University of Iowa Carver College of Medicine, Iowa City, Iowa, USA Search for more papers by this author Author Information J. Thomas Cribbs1 and Stefan Strack 1 1University of Iowa Carver College of Medicine, Iowa City, Iowa, USA *Corresponding author. E-mail: [email protected] EMBO Reports (2007)8:1090-1090https://doi.org/10.1038/sj.embor.7401120 PDFDownload PDF of article text and main figures. ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinked InMendeleyWechatReddit Figures & Info We agree with the letter by Chang & Blackstone (2007a) in its entirety. Their report (Chang & Blackstone, 2007b), which appeared online while our manuscript was under review, independently identified the main cAMP-dependent protein kinase (PKA) phosphorylation site in dynamin-related protein 1 (Drp1) (Ser 637 in human, Ser 656 in rat splice variant 1). Although some discrepancies between our reports in regard to the biochemical characterization of the phospho-site mutants need to be resolved with future experiments, the combined data provide unequivocal evidence for inhibition of Drp1-mediated mitochondrial scission through PKA phosphorylation. Biography J. Thomas Cribbs & Stefan Strack are at the University of Iowa Carver College of Medicine, Iowa City, Iowa, USA References Chang CR, Blackstone C (2007a) Drp1 phosphorylation and mitochondrial regulation. EMBO Rep 8: 1088–1089Wiley Online LibraryCASPubMedWeb of Science®Google Scholar Chang CR, Blackstone C (2007b) Cyclic AMP-dependent protein kinase phosphorylation of Drp1 regulates its GTPase activity and mitochondrial morphology. J Biol Chem 282: 21583–21587CrossrefCASPubMedWeb of Science®Google Scholar Previous ArticleNext Article Volume 8Issue 121 December 2007In this issue ReferencesRelatedDetailsLoading ...