Response by Chao et al to Letters Regarding Article, "Use of Oral Anticoagulants for Stroke Prevention in Patients With Atrial Fibrillation Who Have a History of Intracranial Hemorrhage".

Abstract

We would like to thank Drs Chan and Siu and Drs Yang, An, and Xu for their comments on our recently published article investigating the optimal stroke prevention strategy for patients with atrial fibrillation (AF) with a history of intracranial hemorrhage (ICH).1 We agree that not all ICHs share the same recurrence risk, and the net clinical benefits of warfarin could possibly be offset when a different weight (such as 1.5) is applied for an ICH event. However, in the historic trials, warfarin decreases not only the risk of ischemic stroke but also the risk of all-cause mortality by 26%.2 In the Danish study by …