Abstract
Respiratory viral infections (RVI) are a frequent cause of morbidity and mortality in hematopoietic stem cell transplant (HSCT) patients. We examined clinical characteristics and respiratory viral detection in asymptomatic pediatric HSCT pre-transplant patients and symptomatic post-transplant patients. Coxsackie/echovirus (most common virus detected pre and post-transplant), rhinovirus, and coronavirus were detected pre-transplant and at the first post-transplant event suggesting persistent detection. None of the clinical characteristics examined were associated with viral detection and there was no increase in mortality noted with asymptomatic viral detection.
Highlights
Respiratory viral infections (RVI) are a frequent cause of morbidity and mortality in hematopoietic stem cell transplant (HSCT) patients
Studies on respiratory viruses in the pediatric HSCT transplant population have identified rhinovirus as a common virus found in the pre-transplant period and rhinovirus, coronavirus, parainfluenza virus, respiratory syncytial virus and adenovirus in the post-transplant period [4,7,8,9,10,11]
We evaluated asymptomatic pediatric HSCT patients for the presence of respiratory virus in the immediate pre-transplant period and symptomatic patients for up to 90 days post- transplant to examine epidemiology and clinical characteristics associated with viral detection
Summary
Respiratory viral infections (RVI) are a frequent cause of morbidity and mortality in hematopoietic stem cell transplant (HSCT) patients. We examined clinical characteristics and respiratory viral detection in asymptomatic pediatric HSCT pre-transplant patients and symptomatic post-transplant patients. None of the clinical characteristics examined were associated with viral detection and there was no increase in mortality noted with asymptomatic viral detection. Follow-on post-transplant period and it has been suggested that patients with asymptomatic viral detection do not have increased mortality and those with symptomatic viral detection do have increased mortality [4]. We evaluated asymptomatic pediatric HSCT patients for the presence of respiratory virus in the immediate pre-transplant period and symptomatic patients for up to 90 days post- transplant to examine epidemiology and clinical characteristics associated with viral detection
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Free) 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
