Abstract
Genome studies in ethnic Russians revealed subjects having a heterozygous genotype with allele C at the single-nucleotide polymorphism rs11562975 (G → C), which is in exon 6 of the TRPM8 temperature-sensitive ion channel gene. The subjects had increased sensitivity to cold and produced a hypometabolic response to local skin cooling and to temperature-independent activation of the TRPM8 ion channel by menthol, including a decrease in gas exchange, pulmonary ventilation, and oxygen extraction coefficient. Subjects with the homozygous genotype GG had a lower sensitivity to cold, and their response to local skin cooling was adequate in terms of thermoregulation, including a decrease in respiratory heat loss and an increase in lipid metabolism.
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