Abstract
An investigation was made of the effects of nitrogen dioxide (NO/sub 2/), a combustion-related pollutant reported to depress host resistance to infection, on respiratory patterns in the mouse. Control mice were exposed to filtered air for 3 days; experimental mice were exposed to 5 ppm NO/sub 2/ for the same number of days. After exposure, both control and experimental mice were placed in a respiratory monitor and challenged with clean air (0 ppm NO/sub 2/) or 15, 50, or 100 ppm NO/sub 2/. During the challenge with clean air, there were no differences between groups in respiratory rate (RR), tidal volume (TV), or minute volume (MV). On exposure to NO/sub 2/, RR increased, whereas TV and MV decreased in both groups. RR increased significantly more in control mice, whereas TV decreased to the same extent. MV decreased significantly more in the NO/sub 2/ mice. These results indicate 1) that continual exposure to NO/sub 2/ for 3 days has no effect on subsequent respiration in clean air, but appears to blunt the irritant response to subsequent exposure to NO/sub 2/, and 2) that the depressed host resistance reported earlier is not caused by respiratory changes.
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Schedule a callMore From: Journal of Environmental Science and Health . Part A: Environmental Science and Engineering
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