Abstract
Aspirin, or acetylsalicylic acid (ASA), the first nonsteroidal anti-inflammatory drug (NSAID), has been used for more than 100 years by people around the world for its analgesic, anti-inflammatory, and platelet inhibitory properties [1•]. Within the past 40 years, a variety of NSAIDs have been introduced. Both ASA and NSAIDs are generally well tolerated; however, there are various side effects that can be life threatening. Through their effects on the enzyme cyclooxygenase-1 (COX-1), gastritis and peptic ulcer disease are frequent side effects. Other adverse effects include hepatitis, erythema multiforme, anemia, hepatotoxicity, interstitial nephritis, toxic epidermal necrolysis, and Stevens-Johnson syndrome. Several types of pseudoallergic and allergic reactions to ASA and NSAIDs have been described. Many of these reactions are dependent on their effects on COX-1 inhibition.
Sign-in/Register to access full text options 
Free) 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
