Abstract
In experiments on 35 mongrel albino rats, we studied the effects of a neuropeptide, bombesin (0.2 μl, concentrations from 10-13 to 10-4), which was injected into the nucleus tractus solitarius, on the pattern of respiration and on the electrical activity of the main inspiratory muscles. The local influence of bombesin on this region of the respiratory center led to the expressed intensification of respiration. The respiratory volume and the amplitude of respiratory EMG bursts (oscillatory volleys in the diaphragmatic and external intercostal muscles), as well as the integral intensity of pulmonary ventilation, increased. The maximum deviations of these indices developed under the influence of the peptide in the intermediate concentrations (10-10 to 10-7 M). The observed reactions were characterized by short latencies, rapid development (2 to 5 min long), and relatively short duration. The data obtained are indicative of the possibility of direct involvement of the tested neuropeptide (bombesin) in the control of respiration and confirm concepts on the important role of the dorsal structures of the respiratory center in realization of respiratory effects of neuropeptides.
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